Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core
نویسندگان
چکیده
منابع مشابه
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core
The core domain of the tumour suppressor p53 is of inherently low thermodynamic stability and also low kinetic stability, which leads to rapid irreversible denaturation. Some oncogenic mutations of p53 act by just making the core domain thermosensitive, and so it is the target of novel anti-cancer drugs that bind to and stabilise the protein. Increasing the stability of the unstable core domain...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2009
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzp018